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Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A

Ling Zha1, Tomotaka Sobue1, Taro Takeuchi1

  • 1Environmental Medicine and Population Sciences, Department of Social Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan.

Journal of Clinical Medicine
|July 2, 2021
PubMed

Insights

This study analyzed 205 intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19) in Japan. Older age, particularly over 80, significantly increased mortality risk in ICU patients with COVID-19.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Limited data exists on the intensive care unit (ICU) management and outcomes for coronavirus disease 2019 (COVID-19) patients in Japan.
  • Understanding the characteristics of severe COVID-19 cases is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To evaluate the epidemiological and clinical features, treatments, and outcomes of COVID-19 patients admitted to ICUs in Osaka Prefecture, Japan.
  • To identify factors associated with mortality in this patient cohort.

Main Methods:

  • Analysis of registry data from 205 COVID-19 ICU patients admitted between February and November 2020.
  • Utilized a Cox proportional hazards model to assess mortality risk factors.
  • Follow-up data on patient outcomes at discharge.

Main Results:

  • The majority of ICU patients were male (78.5%) and over 60 years old (72.7%).
  • Comorbidities were present in 57.1% of patients; 91.2% required mechanical ventilation, and 15.6% needed extracorporeal membrane oxygenation.
  • Mortality rate was 28.3%; patients over 80 years old had a significantly higher hazard ratio for mortality (6.02) compared to those ≤59 years old.

Conclusions:

  • The study highlights the significant impact of age, particularly advanced age, on mortality risk in severe COVID-19 patients requiring ICU care.
  • Findings provide valuable insights into the clinical course and prognosis of COVID-19 in Japanese ICU settings.
  • Data can inform clinical decision-making and resource allocation for severe COVID-19 cases.

Keywords:
COVID-19Japanageintensive care unit (ICU)mortalitysurvival analysis

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