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Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors
Róbert Berkecz1, Dániel Tanács1, Antal Péter1
1Interdisciplinary Excellence Centre, Institute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, H-6720 Szeged, Hungary.
Molecules (Basel, Switzerland)
|July 2, 2021
Summary
Chiral separation is crucial for pharmaceuticals. Macrocyclic glycopeptides offer advanced chiral stationary phases for efficient enantiomeric separations in liquid chromatography.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Science
- Organic Chemistry
Background:
- Chiral compounds are vital in pharmaceuticals, fertilizers, and food additives, often sold as racemic mixtures.
- Only one enantiomer typically exhibits desired biological activity, necessitating enantiomeric separation.
- Advancements in understanding chiral compound bioactivity drive demand for efficient enantiomeric separation methods.
Purpose of the Study:
- To review direct liquid chromatography methods for enantiomeric separations.
- To highlight the utility of macrocyclic glycopeptide-based chiral selectors.
- To detail the physico-chemical properties and recent applications of these selectors.
Main Methods:
- Focus on direct liquid chromatography techniques.
- Utilize chiral stationary phases (CSPs).
- Employ macrocyclic glycopeptide antibiotics as chiral selectors.
Main Results:
- Macrocyclic glycopeptide-based CSPs are highly effective for separating biologically and pharmacologically relevant enantiomers.
- Numerous such CSPs are commercially available.
- Recent applications demonstrate their versatility and efficiency.
Conclusions:
- Macrocyclic glycopeptides represent a powerful class of chiral selectors for enantiomeric separations.
- Direct liquid chromatography with these selectors is a sophisticated analytical tool.
- Continued research and application of these selectors are essential for pharmaceutical development.
Keywords:
chiral stationary phasesenantiomer separationsliquid chromatographymacrocyclic glycopeptide antibioticsMore Related Videos
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