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Updated: Oct 30, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases

Lih-Fhung Hiew1, Chi-Him Poon1, Heng-Ze You1

  • 1Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Cells
|July 2, 2021
PubMed

Insights

Transforming growth factor-beta (TGF-β)/Smad signaling influences neurogenesis and is implicated in mood disorders. This review explores TGF-β/Smad pathways, neurogenesis, and their link to stress response and behavioral outcomes.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Transforming growth factor-beta (TGF-β)/Smad signaling is crucial for cell cycle regulation and carcinogenesis.
  • Dysregulation of TGF-β/Smad signaling impacts neurogenesis, the process of generating new neurons.
  • Neurogenesis plays a role in neuropsychiatric disorders, including mood disorders.

Purpose of the Study:

  • To review current research on canonical and non-canonical TGF-β/Smad signaling pathways.
  • To examine the function of these pathways in neurogenesis.
  • To explore the link between TGF-β/Smad signaling, neurogenesis, and neuropsychiatric disorders under stress.

Main Methods:

  • Literature review of existing research on TGF-β/Smad signaling and neurogenesis.
  • Analysis of studies investigating neurogenesis in the context of neuropsychiatric disorders.
  • Examination of the relationship between TGF-β/Smad signaling and stress response mechanisms.

Main Results:

  • TGF-β/Smad signaling pathways (canonical and non-canonical) have diverse effects on neurogenesis.
  • Neurogenesis is significantly altered in various neuropsychiatric disorders.
  • Stressors modulate TGF-β/Smad signaling and neurogenesis, influencing behavioral outcomes.

Conclusions:

  • TGF-β/Smad signaling is a key regulator of the stress response.
  • The pathway is implicated in the development and behavioral manifestations of mood disorders.
  • Understanding TGF-β/Smad signaling in neurogenesis offers insights into neuropsychiatric conditions.
Keywords:
TGF-βdepressionneurogenesissmadstress

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