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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Maxillary Sinus Augmentation Using Ceramic Alloplastic Granules or Paste: An Experimental Study in Rabbits.

Michael Medeiros Costa1, Daniele Botticelli2, Ofer Moses3

  • 1Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil.

Dentistry Journal
|July 2, 2021
PubMed
Summary

Granules of an alloplastic graft showed faster new bone formation than paste during maxillary sinus lifts in rabbits. Further study is needed to confirm the paste formulation

Keywords:
alloplasticanimal studybone healingcollagen membranehistomorphometrysinus floor elevation

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Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Regenerative Medicine

Background:

  • Limited data exists comparing the biological behavior of alloplastic graft formulations (granules vs. paste).
  • Microtomographic and histomorphometric analyses are crucial for evaluating bone healing after sinus lifts.

Purpose of the Study:

  • To compare the histomorphometric and microtomographic healing of granular (MR sites) versus paste (MR-inject sites) alloplastic grafts.
  • To evaluate the efficacy of beta-tricalcium phosphate and hydroxyapatite combination in two formulations for maxillary sinus lifting.

Main Methods:

  • Maxillary sinus lifting was performed bilaterally in 20 rabbits.
  • The elevated space was filled with either paste or granular alloplastic material.
  • Animals were euthanized at 2 or 10 weeks for microtomographic and histological analyses.

Main Results:

  • Granular alloplastic grafts (MR sites) demonstrated significantly higher new bone formation compared to paste (MR-inject sites) at both 2 weeks (2.65% vs. 0.08%) and 10 weeks (34.20% vs. 23.28%).
  • Statistical significance (p < 0.01 at 2 weeks, p = 0.022 at 10 weeks) was observed for new bone formation between the two formulations.

Conclusions:

  • New bone formation was faster with the granular formulation (MR sites) compared to the paste formulation (MR-inject sites).
  • Longer healing periods may be necessary to definitively assess the bone formation efficiency of the paste formulation.