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Related Experiment Video

Updated: Oct 30, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

4.0K

Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording.

Saeyeong Jeon1, Youjin Lee2,3, Daeho Ryu1

  • 1Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Korea.

Micromachines
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel optrode array combining optogenetics and electrophysiology for precise neural control and recording. This new device enables effective optical activation and simultaneous neural activity monitoring in vivo.

Keywords:
channelrhodopsinelectrodeelectrophysiologyoptogeneticsoptrode

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optogenetics

Background:

  • Optogenetics enables cell-type-specific neuromodulation, a crucial technique in neuroscience.
  • Technological advancements in light delivery are enhancing optogenetic applications.
  • Integrating optogenetics with electrophysiology offers synergistic benefits for neural research.

Purpose of the Study:

  • To propose and characterize a novel optrode array design.
  • To integrate optical modulation and electrophysiological recording capabilities.
  • To validate the device's performance in vivo.

Main Methods:

  • A 4x4 optrode array combined with five-channel recording electrodes was designed as a disposable component.
  • A reusable component integrated an LED light source and power line.
  • Light intensity at fiber tips was characterized.
  • In vivo experiments were conducted using transgenic mice expressing channelrhodopsin.

Main Results:

  • The optrode array successfully integrated optical stimulation and electrophysiological recording.
  • Characterization confirmed light delivery intensity at fiber tips.
  • In vivo experiments demonstrated effective optical activation of neurons.
  • Simultaneous neural recording confirmed the device's functionality.

Conclusions:

  • The novel optrode array design effectively combines optogenetics and electrophysiology.
  • The device facilitates precise optical control and simultaneous neural recording.
  • This integrated approach advances neuroscience research capabilities.