A Radionuclide Generator of High-Purity Bi-213 for Instant Labeling

A new two-column ²²⁵Ac/²¹³Bi generator was developed specifically for using ²²⁵Ac containing an impurity of long lived ²²⁷Ac. The parent ²²⁵Ac was retained on the first Actinide Resin column, while ²¹³Bi was accumulated on the second column filled with AG MP-50 resin via continuous elution and decay of intermediate ²²¹Fr. The ²¹³Bi accumulation was realized in circulation mode which allowed a compact generator design. It was demonstrated that ²¹³Bi could be quickly and effectively extracted from AG MP-50 in form of complexes with various chelating agents including DTPA and DOTA. The performance of the generator presented and a conventional single-column generator on the base of AG MP-50 was tested and both generators were loaded with ²²⁵Ac containing ²²⁷Ac impurity. The ²¹³Bi generation efficiencies were comparable and greater than 70%, whereas the developed generator provided a deeper degree of purification of ²¹³Bi from Ac isotopes and decay products of ²²⁷Ac.