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An Updated Understanding of the Role of YAP in Driving Oncogenic Responses

Giampaolo Morciano1, Bianca Vezzani1, Sonia Missiroli1

  • 1Laboratory for Technologies of Advanced Therapies (LTTA), Section of Experimental Medicine, Department of Medical Science, University of Ferrara, 44121 Ferrara, Italy.

Cancers
|July 2, 2021
PubMed

Insights

Yes-associated protein (YAP) is a key oncogene in cancer, regulating tumor growth and metastasis. Understanding YAP

Area of Science:

  • Oncology and Molecular Biology
  • Cancer Signaling Pathways
  • Cellular Regulation

Background:

  • Yes-associated protein (YAP) is a potent oncogene central to cancer signaling.
  • Nuclear YAP drives oncogenic processes like cell transformation, tumor growth, migration, and metastasis.
  • YAP also mediates crucial interactions between immune and cancer cells.

Purpose of the Study:

  • To review the current knowledge on YAP's role in cancer signaling.
  • To differentiate YAP from WWTR1/TAZ and identify its upstream regulators.
  • To explore YAP's involvement in various cancer stages, immune-cancer crosstalk, and therapeutic strategies.

Main Methods:

  • Literature review and synthesis of existing research on YAP.
  • Comparative analysis of YAP and WWTR1/TAZ functions.
  • Examination of YAP's role in cancer progression and therapeutic interventions.

Main Results:

  • YAP's complex regulatory mechanisms and its cytoplasmic retention offer novel therapeutic insights.
  • YAP's distinct functions compared to WWTR1/TAZ are highlighted.
  • YAP's multifaceted role across cancer stages and its interaction with therapies are detailed.

Conclusions:

  • YAP is a critical oncogene with diverse roles in cancer development and progression.
  • Understanding YAP regulation and localization is key to developing new anticancer treatments.
  • Targeting YAP, alone or in combination with existing therapies, presents promising translational strategies.
Keywords:
Hippo pathwayYAPcancerimmunitytargeted therapies

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