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Related Experiment Video

Updated: Oct 30, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

From A to m⁶A: The Emerging Viral Epitranscriptome.

Belinda Baquero-Perez¹, Daryl Geers¹, Juana Díez¹

¹Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

|July 2, 2021

Summary

The epitranscriptome includes over 100 RNA modifications, with N6-methyladenosine (m6A) being key in regulating mRNA. This review details m6A

Keywords:

RNA modification epitranscriptomics m6A viral infection

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Last Updated: Oct 30, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

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Published on: March 5, 2022

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Area of Science:

Molecular Biology
Virology
Epigenetics

Background:

The epitranscriptome encompasses over 100 chemical RNA modifications.
N6-methyladenosine (m6A) is the most prevalent internal modification in cellular messenger RNAs (mRNAs).
m6A regulates critical mRNA processes including structure, stability, translation, and nuclear export.

Purpose of the Study:

To provide a comprehensive review of N6-methyladenosine (m6A) modification.
To emphasize the role and function of m6A in virus biology.
To explore the interaction between viral RNA and the cellular m6A machinery.

Main Methods:

Literature review and synthesis of existing research.
Analysis of studies investigating m6A in viral RNA genomes and mRNAs.
Examination of the interplay between viral replication and cellular m6A regulatory pathways.

Main Results:

m6A modification is present in viral RNA genomes and mRNAs from both RNA and DNA viruses.
Evidence suggests m6A plays significant roles in regulating viral replication.
The cellular m6A machinery interacts with viral components to influence infection outcomes.

Conclusions:

m6A is a crucial epitranscriptomic mark with significant implications in virology.
Understanding m6A's role in viral biology offers potential therapeutic targets.
Further research into the m6A epitranscriptome in virus-host interactions is warranted.