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Related Concept Videos

Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

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In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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An Improved Time- and Labor- Efficient Protocol for Mouse Primary Hepatocyte Isolation
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Hepatocrinology.

Sanjay Kalra1, Saptarshi Bhattacharya2, Pawan Rawal3

  • 1Department of Endocrinology, Bharti Hospital, Karnal 132001, India.

Medical Sciences (Basel, Switzerland)
|July 2, 2021
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Summary

Hepatocrinology explores the complex link between liver health and hormones. This field examines how liver conditions affect endocrine function and vice versa, highlighting hepato-endocrine syndromes.

Keywords:
NAFLDcirrhosisdiabetesendocrinehepatogenous diabetesliver

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Area of Science:

  • Endocrinology
  • Hepatology
  • Internal Medicine

Background:

  • The liver and endocrine system have intricate bidirectional interactions.
  • Hepatic diseases can lead to endocrine dysfunction, and endocrine disorders can impact liver health.
  • Hepatotropic and endocrine drugs can influence each other's efficacy and safety profiles.

Purpose of the Study:

  • To define hepatocrinology as a distinct field of study.
  • To outline the scope of hepatocrinology, including hepato-endocrine syndromes.
  • To encourage further research and clinical attention in this area.

Main Methods:

  • Conceptual review and synthesis of existing knowledge.
  • Definition and scope delineation of hepatocrinology.
  • Identification of hepato-endocrine syndromes.

Main Results:

  • Hepatocrinology is established as the study of the liver-endocrine axis.
  • The field encompasses diverse etiologies of hepato-endocrine syndromes.
  • A framework for understanding drug interactions between hepatotropic and endocrine agents is presented.

Conclusions:

  • Hepatocrinology offers a unified perspective on liver-endocrine interactions.
  • Recognizing hepato-endocrine syndromes is crucial for comprehensive patient care.
  • Further investigation into hepatocrinology is warranted to advance medical understanding and treatment.