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Related Concept Videos

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

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Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Thiol- and Disulfide-Based Stimulus-Responsive Soft Materials and Self-Assembling Systems.

Danielle M Beaupre1, Richard G Weiss1,2

  • 1Department of Chemistry, Georgetown University, Washington, DC 20057, USA.

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|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Synthetic thiol- and disulfide-based polymers offer stimulus-responsive and self-healing properties. These advanced materials are useful in both biomedical and non-biomedical applications due to their unique chemical behavior.

Keywords:
disulfide-disulfide metathesisdrug deliveryredox-responsiveself-healingstimulus-responsive materialsthiol-disulfide exchange

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Thiol and disulfide chemistries are fundamental in developing advanced synthetic materials.
  • Soft and self-assembling materials are gaining traction for dynamic applications.
  • Stimulus-responsive and self-healing properties are highly desirable in modern materials.

Purpose of the Study:

  • To review the properties and applications of synthetic thiol- and disulfide-based materials.
  • To highlight soft and self-assembling materials within this class.
  • To emphasize the role of thiol-disulfide interconversion in material function.

Main Methods:

  • Literature review focusing on synthetic thiol- and disulfide-based polymers.
  • Analysis of materials exhibiting soft and self-assembling characteristics.
  • Examination of stimulus-response and self-healing mechanisms driven by thiol-disulfide chemistry.

Main Results:

  • Synthetic thiol- and disulfide-based polymers possess diverse properties.
  • Interconversion of thiol and disulfide groups enables stimulus-responses.
  • These materials demonstrate significant potential for self-healing capabilities.

Conclusions:

  • Thiol- and disulfide-based polymers are versatile materials with tunable properties.
  • Their ability to respond to stimuli and self-heal opens avenues for innovative applications.
  • Applications span both biomedical and non-biomedical fields, showcasing broad utility.