Related Experiment Video For dysbiosis
Updated: Oct 30, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
Jinghang Xu1, Qiao Zhan1, Yanan Fan1
1Department of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, China.
Abstract:
Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development.
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