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Updated: Oct 30, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Molecular Genetics in Epstein-Barr Virus-Associated Malignancies
Srikanth Umakanthan1, Maryann M Bukelo2
1Pathology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Mount Hope, Trinidad and Tobago.
Abstract:
Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein-Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.
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