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Related Experiment Videos

Apheresis experience with a continuous flow cell separator.

F Norol1, C Aubert, F Scotto

  • 1Centre Départmental de Transfusion Sanguine du Val de Marne, Hôpital Henri Mondor, Creteil, France.

Transfusion
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

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The Dideco Vivacell separator effectively collects platelets and white blood cells during cytapheresis. This continuous-flow system demonstrates high yields and good cell function with rare donor reactions.

Area of Science:

  • Hematology
  • Biomedical Engineering
  • Cellular Biology

Background:

  • Continuous-flow centrifugation systems are increasingly utilized for apheresis procedures.
  • The Dideco Vivacell separator is a newer system recently adapted for cytapheresis.

Purpose of the Study:

  • To evaluate the efficacy and safety of the Dideco Vivacell separator for plateletpheresis and leukapheresis.
  • To assess platelet yield, collection efficiency, and functional integrity.
  • To determine white blood cell yields and functional status post-collection.

Main Methods:

  • The study analyzed data from 451 plateletpheresis and 164 leukapheresis procedures using the Dideco Vivacell separator.
  • Platelet functional integrity was assessed through in vitro tests (aggregation, hypotonic stress response) and in vivo recovery.

Related Experiment Videos

  • White blood cell oxidative metabolism was investigated using chemiluminescence.

    • Main Results:

    • High platelet yields (9.53 +/- 2.85 X 10(11)) and collection efficiency (74 +/- 14%) were achieved, with preserved platelet function.
    • Leukapheresis procedures yielded high numbers of white blood cells (3.42 +/- 1.2 X 10(10)), predominantly polymorphonuclear neutrophils (85%).
    • Increased oxidative metabolism was observed in collected white blood cells, and donor reactions were infrequent and mild (citrate-related).

    Conclusions:

    • The Dideco Vivacell separator is an effective device for both platelet and white blood cell collection via cytapheresis.
    • The system ensures high yields and maintains the functional integrity of collected blood components.
    • The Dideco Vivacell separator offers a safe apheresis option with a low incidence of adverse events.