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Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
Published on: February 23, 2024
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Obesity and Multiple Sclerosis-A Multifaceted Association
Thomas-Gabriel Schreiner1,2,3, Tudor-Marcel Genes1,2
1Neurology Department, Clinical Rehabilitation Hospital, 700661 Iași, Romania.
Journal of Clinical Medicine
|July 2, 2021
Summary
Childhood and adolescent obesity significantly increase the risk of developing multiple sclerosis (MS). Further research is needed to understand the link between obesity, MS pathophysiology, and adipokines.
Area of Science:
- Neuroimmunology
- Endocrinology
- Epidemiology
Background:
- Obesity and multiple sclerosis (MS) share common inflammatory pathophysiological pathways.
- Obesity's inflammatory component is increasingly linked to chronic diseases, including MS.
Purpose of the Study:
- To elucidate the intricate relationship between obesity and MS.
- To examine the causal link between early-life obesity and MS development.
- To review current understanding of shared pathophysiological mechanisms.
Main Methods:
- Comprehensive literature search of major electronic databases (PubMed, Google Scholar, Embase, Science Direct) conducted in February 2021.
- Focus on relevant articles published within the last 10 years.
- Inclusion of epidemiological and pathophysiological studies.
Main Results:
- Epidemiological data suggest a strong association between early-life obesity and increased MS risk, independent of other factors.
- Recent findings on pathophysiological mechanisms linking obesity and MS, including the role of adipokines, are discussed.
Conclusions:
- Early-life obesity is a significant risk factor for MS development.
- Further research is required to fully understand the shared mechanisms and the role of adipokines.
- Data on obesity's impact on MS disability and mortality remain insufficient.
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