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Updated: Oct 30, 2025

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The Hidden Role of Hydrogen Sulfide Metabolism in Cancer
Rong-Hsuan Wang1, Yu-Hsin Chu1,2, Kai-Ti Lin1,3
1Institute of Biotechnology, College of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan.
Abstract:
Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H2S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H2S plays various roles during cancer development reveals opportunities to target H2S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H2S-mediated protein persulfidation and the detailed information about the dysregulation of H2S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H2S-mediated cancer progression and summarize current options to modulate H2S production for cancer therapy.
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