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Updated: Oct 30, 2025

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MUC1: Structure, Function, and Clinic Application in Epithelial Cancers.

Wenqing Chen1, Zhu Zhang2, Shiqing Zhang2

  • 1Division of Teaching and Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

International Journal of Molecular Sciences
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Mucin 1 (MUC1) functions differently in normal and cancer cells. Aberrant MUC1 in cancer drives invasion and metastasis, offering potential therapeutic targets.

Keywords:
MUC1MUC1 cell barrierepithelial cancerimmunotherapytherapeutic biomarkerstumor oncogene

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Mucin 1 (MUC1) is a transmembrane glycoprotein with diverse biological roles.
  • In normal cells, MUC1 acts as a lubricant, moisturizer, and barrier.
  • In cancer, MUC1 exhibits aberrant glycosylation and overexpression, impacting cellular processes.

Purpose of the Study:

  • To review the biological structure and functions of MUC1 in normal and cancerous cells.
  • To elucidate the regulatory mechanisms controlling MUC1's roles.
  • To evaluate MUC1's therapeutic potential in cancer treatment.

Main Methods:

  • Literature review of MUC1's structure, function, and regulation.
  • Analysis of MUC1's involvement in cancer progression (invasion, metastasis, angiogenesis, apoptosis).
  • Assessment of current research on MUC1-targeted cancer therapies.

Main Results:

  • MUC1's dual role in normal physiology versus oncogenesis.
  • MUC1's participation in key cancer signaling pathways.
  • Identification of MUC1 as a potential biomarker and therapeutic target.

Conclusions:

  • MUC1's aberrant expression and function are critical in cancer development.
  • Understanding MUC1's mechanisms offers avenues for novel cancer therapies.
  • MUC1-based strategies show promise for clinical application in oncology.