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A Multidisciplinary Approach to Coronavirus Disease (COVID-19)
Aliye Gediz Erturk1, Arzu Sahin2, Ebru Bati Ay3
1Department of Chemistry, Faculty of Arts and Sciences, Ordu University, Altınordu, Ordu 52200, Turkey.
Molecules (Basel, Switzerland)
|July 2, 2021
Summary
This review explores chemical and therapeutic strategies against COVID-19, including drug design, immunotherapy, and natural products. It synthesizes research on SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) to combat the global health threat.
Area of Science:
- Virology and Medicinal Chemistry
- Immunology and Pharmacology
Background:
- The emergence of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) since December 2019 presents a significant global health challenge.
- Extensive research has focused on understanding the virus's origin, structure, mechanism of action, and disease treatment.
Purpose of the Study:
- To review chemical studies and therapeutic strategies for overcoming COVID-19.
- To screen newly synthesized compounds, repurposed therapeutics, and natural products against SARS-CoV-2.
- To highlight computer-aided drug design approaches for developing anti-COVID-19 molecules.
Main Methods:
- Comprehensive literature review of chemical studies and therapeutic approaches.
- Screening of synthesized compounds, repurposed drugs (antiviral, anti-inflammatory, etc.), and natural products.
- Analysis of computer-aided drug design methodologies and immunotherapy strategies.
Main Results:
- Identified various therapeutic avenues including immunotherapy, vaccines, novel molecular structures, and repurposed drugs.
- Highlighted the potential of phytochemicals and dietary supplements as antiviral agents against COVID-19.
- Discussed computer-aided approaches for designing effective anti-COVID-19 molecules.
Conclusions:
- A multi-faceted approach combining chemical synthesis, drug repurposing, immunotherapy, and natural products is crucial for combating COVID-19.
- Further research into computer-aided design and natural product efficacy can accelerate the development of novel therapeutics.
Keywords:
COVID-19SARS-CoV-2cytokine stormdietary supplementsimmunotherapyin-silico researchnatural productsrepurposing drugssmall drugsvaccine developmentMore Related Videos
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