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Updated: Oct 30, 2025
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Microscopy of Fission Yeast Sexual Lifecycle
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Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
Vedrana Andric1,2, Mathieu Rougemaille1
1Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198 Gif-sur-Yvette, France.
Non-Coding RNA
|July 2, 2021
Summary
Long non-coding RNAs (lncRNAs) regulate gene expression during the cell cycle transition from mitosis to meiosis in yeast. These crucial molecules guide gamete production and genetic inheritance.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators of gene expression and genome stability.
- The transition from mitosis to meiosis involves significant gene expression changes for gamete production.
Purpose of the Study:
- To review the biology and function of lncRNAs in fission yeast meiosis.
- To discuss the regulatory mechanisms of lncRNAs in gametogenesis.
Main Methods:
- Literature review of studies on lncRNAs in *Schizosaccharomyces pombe*.
- Analysis of lncRNA roles in cell cycle regulation and meiosis-specific events.
Main Results:
- lncRNAs orchestrate cell cycle-dependent transcriptomes during the mitosis-meiosis transition.
- These lncRNAs employ diverse mechanisms, including epigenetic modifications and transcriptional/post-transcriptional regulation.
- lncRNAs are essential for meiosis-specific chromosomal events.
Conclusions:
- lncRNAs play a critical role in controlling gametogenesis in fission yeast.
- Understanding lncRNA mechanisms provides insights into cell fate determination and genetic inheritance.
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