Multi-Functional Core-Shell Nanofibers for Wound Healing.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Core-shell nanofibers show promise for advanced wound healing dressings, enabling controlled release of multiple therapeutic agents.
• Current methods for producing core-shell nanofibers often face challenges with high production rates and energy efficiency.
• Effective drug delivery strategies are crucial for managing different phases of the wound healing process.

Purpose of the Study:

• To design and assemble a co-axial centrifugal spinning device for efficient core-shell nanofiber production.
• To investigate the controlled release of ibuprofen and human epidermal growth factor (hEGF) for wound healing applications.
• To demonstrate the potential of co-axial centrifugal spinning for creating 3D scaffolds that mimic natural tissue.

Main Methods:

• Development and implementation of a novel co-axial centrifugal spinning apparatus.
• Fabrication of core-shell nanofibers encapsulating specific therapeutic agents.
• Characterization of core-shell nanofiber structure using Transmission Electron Microscopy (TEM).
• Evaluation of drug release profiles for controlled delivery during wound healing phases.

Main Results:

• Successful fabrication of core-shell nanofibers confirmed by TEM.
• Demonstration of controlled release of ibuprofen and hEGF from the nanofiber layers.
• Co-axial centrifugal spinning proved to be a high-productivity method for nanofiber production.
• The 3D nanofiber structure effectively mimics natural tissue scaffolds.

Conclusions:

• Co-axial centrifugal spinning is an effective technique for producing core-shell nanofibers with controlled drug release capabilities.
• This method offers a high-throughput and energy-efficient approach for creating advanced wound healing materials.
• Layered drug incorporation allows for tailored release kinetics, enhancing therapeutic efficacy and promoting wound healing.