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COVID-19 and Delayed Cerebral Ischemia-More in Common Than First Meets the Eye

Pervinder Bhogal1, Levansri Makalanda1, Ameer E Hassan2

  • 1Department of Interventional Neuroradiology, The Royal London Hospital, Barts NHS Trust, Whitechapel Road, Whitechapel, London E1 1BB, UK.

Journal of Clinical Medicine
|July 2, 2021
PubMed

Insights

COVID-19 infection causes endotheliopathy and microthrombosis, similar to aneurysmal sub-arachnoid haemorrhage (SAH). Understanding these shared pathological mechanisms may reveal new treatment options for both conditions.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Neurology

Background:

  • The COVID-19 pandemic has spurred research into its pathological mechanisms.
  • COVID-19 is increasingly understood to induce widespread endotheliopathy, leading to thrombosis, particularly microthrombosis.
  • Aneurysmal sub-arachnoid haemorrhage (SAH) patients also exhibit endotheliopathy and microthrombosis.

Purpose of the Study:

  • To elucidate the similarities in pathological processes between COVID-19 and SAH.
  • To explore potential therapeutic strategies based on shared disease mechanisms.

Main Methods:

  • Comparative analysis of pathological findings in COVID-19 and SAH.
  • Review of existing literature on endotheliopathy and microthrombosis in both conditions.

Main Results:

  • Evidence suggests overlapping mechanisms of endotheliopathy and microthrombosis in COVID-19 and SAH.
  • These shared pathways involve endothelial dysfunction and subsequent microvascular complications.

Conclusions:

  • COVID-19 and SAH share common pathophysiological pathways involving endotheliopathy and microthrombosis.
  • Targeting these shared mechanisms could offer novel therapeutic avenues for both diseases.

Keywords:
COVID-19delayed cerebral ischemiamicrothrombosissubarachnoid haemorrhage

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