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MMP-2 and MMP-9 Polymorphisms and Preeclampsia Risk in Tunisian Arabs: A Case-Control Study.

Marwa Ben Ali Gannoun1,2, Nozha Raguema1,3,4, Hedia Zitouni1

  • 1Laboratory of Human Genome and Multifactorial Diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir 5000, Tunisia.

Journal of Clinical Medicine
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Genetic variations in matrix metalloproteinase-9 (MMP-9) are linked to preeclampsia risk. The MMP-9 -1562 C/T polymorphism may increase susceptibility to this hypertensive disorder of pregnancy.

Keywords:
MMP-2MMP-9SNPsgenotypingpreeclampsia

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Area of Science:

  • Genetics
  • Obstetrics
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs), particularly MMP-9 and MMP-2, are implicated in hypertensive disorders of pregnancy.
  • Functional genetic polymorphisms in MMP gene promoters can alter MMP expression, potentially influencing preeclampsia development.

Purpose of the Study:

  • To investigate the association between MMP-9 (rs3918242, -1562 C>T) and MMP-2 (rs2285053, -735 C>T) gene polymorphisms and preeclampsia risk.
  • To evaluate the role of these genetic variants in preeclampsia pathogenesis among Tunisian women.

Main Methods:

  • A case-control study involving 345 women with preeclampsia and 281 healthy pregnant women.
  • Genotyping of MMP-9 -1562 C>T and MMP-2 -735 C>T polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Main Results:

  • An increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers was observed in women with preeclampsia (p = 0.03).
  • No significant difference in allele or genotype frequencies for the MMP-2 -735 C>T polymorphism was found between preeclampsia cases and controls.

Conclusions:

  • The MMP-9 -1562 C/T variant, potentially leading to higher MMP-9 production, may represent a genetic risk factor for preeclampsia in the Tunisian population.
  • MMP-2 -735 C>T polymorphism does not appear to be associated with preeclampsia risk in this cohort.