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Updated: Oct 30, 2025
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Published on: February 16, 2022
Serology in COVID-19: Comparison of Two Methods
Anna Moniuszko-Malinowska1, Wojciech Jelski2, Justyna Dunaj1
1Department of Infectious Diseases, Neuroinfections Medical University in Bialystok, Żurawia 14, 15-540 Białystok, Poland.
Background:
The aim of our study was to examine the performance of two assays in detecting SARS-CoV-2 antibodies.
Methods:
A total of 127 COVID-19 disease contacts from the Infectious Diseases Department were included. Two serological tests were used: SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) and LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin).
Results:
The assays exhibited a 96.85% (123/127 patients) test result agreement. In two cases, the positive results obtained by SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) were negative based on the LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test, and in two cases, negative results from the LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test were positive with the SARS-CoV-2 IgG CMIA on the Alinity system (Abbott).
Conclusions:
Based on the results of our study, we conclude that in population medicine, the assessments of anti-SARS-CoV-2 antibodies after exposure to SARS-CoV-2 virus based on spike protein or nucleocapsid protein show comparable effectiveness.
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