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TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and

Eleonora Pauletto1, Nils Eickhoff2, Nuno A Padrão2

  • 1Institute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology, PO-Box 3640, 76021 Karlsruhe, Germany.

Cells
|July 2, 2021
PubMed

Insights

Tripartite motif (TRIM) proteins impact hormone-driven cancers like prostate and breast cancer. Understanding TRIM proteins offers new ways to diagnose and treat these common cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The tripartite motif (TRIM) protein family is structurally defined and functionally diverse.
  • TRIM proteins are implicated in various diseases, including cancer.
  • Hormone-driven cancers represent a significant cause of cancer-related mortality.

Purpose of the Study:

  • To review the biological impact of TRIM proteins in hormone-driven cancers.
  • To explore TRIM protein roles in relation to hormone receptor biology and hormone-independent mechanisms.
  • To identify common TRIM protein functions across prostate, breast, ovarian, and endometrial cancers.

Main Methods:

  • Literature review focusing on TRIM proteins in hormone-driven cancers.
  • Analysis of TRIM protein involvement in hormone receptor signaling.
  • Examination of TRIM protein roles in hormone-independent tumor cell biology.

Main Results:

  • TRIM proteins exhibit both tumor-suppressive and oncogenic activities in hormone-driven cancers.
  • TRIM proteins influence hormone receptor biology and hormone-independent cancer pathways.
  • Common functional themes for TRIM proteins exist across prostate, breast, ovarian, and endometrial cancers.

Conclusions:

  • TRIM proteins play a significant role in the biology of hormone-driven cancers.
  • Further understanding of TRIM proteins can lead to improved cancer prognostication.
  • Targeting TRIM proteins may offer novel therapeutic strategies for hormone-driven cancers.
Keywords:
E3 ligasesRINGTRIM proteinshormone-related cancerssteroid hormonesubiquitin

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