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Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells

Yukyung Hong1, Jaehak Lee1, Hyunjin Moon1

  • 1College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.

Cancers
|July 2, 2021
PubMed

Insights

New research identifies NAG-1 as a potential biomarker for thyroid cancer prognosis. This protein may also serve as a therapeutic target, potentially improving diagnosis and treatment strategies for thyroid cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Thyroid cancer treatment lacks specific diagnostic and prognostic markers, leading to unnecessary surgeries.
  • Novel biomarkers are crucial for improving the diagnosis and treatment of thyroid cancer.

Purpose of the Study:

  • To identify novel biomarkers for thyroid cancer diagnosis and prognosis.
  • To investigate the role of NAG-1 in thyroid cancer and its potential as a therapeutic target.

Main Methods:

  • Antibody arrays were used to analyze tumor and adjacent normal tissues from papillary thyroid cancer patients.
  • Western blot analysis was performed to assess pro-NAG-1 and mature NAG-1 expression.
  • The effect of phytochemicals and NSAIDs on pro-NAG-1 expression was evaluated.
  • NAG-1 promoter activity was examined to understand regulatory mechanisms.

Main Results:

  • Mature NAG-1 expression was higher in tumor tissues, while pro-NAG-1 expression was higher in normal tissues.
  • Phytochemicals and NSAIDs, particularly quercetin, dose-dependently increased pro-NAG-1 expression.
  • Quercetin treatment enhanced anticancer activity, including apoptosis and cell cycle arrest.
  • p53, C/EBPα, and C/EBPδ were identified as key factors in quercetin-induced NAG-1 expression.

Conclusions:

  • NAG-1 shows potential as a novel prognostic biomarker for thyroid cancer.
  • NAG-1 may be a viable therapeutic target for thyroid cancer treatment.
  • Understanding NAG-1 regulation can inform future therapeutic strategies.
Keywords:
C/EBPGDF15mature NAG-1pro-NAG-1quercetinthyroid cancer

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