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Metal-Organic Frameworks-Based Nanomaterials for Drug Delivery
Mohammad Reza Saeb1, Navid Rabiee2, Masoud Mozafari3
1LMOPS, CentraleSupélec, Université de Lorraine, F-57000 Metz, France.
Materials (Basel, Switzerland)
|July 2, 2021
Summary
Nanoscale metal-organic frameworks (NMOFs) offer tunable, porous structures for drug delivery. Their flexibility, biodegradability, and functionalization potential make them promising nanocarriers for anticancer therapies.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedicine
Background:
- Metal-organic frameworks (MOFs) possess tunable composition and topology, offering high porosity and surface area (≈3000-6000 m²·g⁻¹).
- Nanoscale MOFs (NMOFs) have emerged as significant porous nanomaterials for biomedical applications, particularly as nanocarriers.
- NMOFs present advantages over other nanocarriers like nanosilica, nanomicelles, and dendrimers, including enhanced flexibility, biodegradability, and functionalization capabilities.
Purpose of the Study:
- To highlight the potential of nanoscale metal-organic frameworks (NMOFs) as advanced nanocarriers for biomedical applications.
- To emphasize the unique properties of NMOFs that make them suitable for drug and gene delivery, especially for anticancer cargos.
- To discuss the versatility of NMOF synthesis in various morphologies for optimized drug encapsulation and release.
Main Methods:
- Literature review and synthesis of existing research on MOFs and NMOFs in biomedicine.
- Comparative analysis of NMOFs against other nanoparticle-based delivery systems.
- Exploration of NMOF properties such as porosity, surface area, biodegradability, functionalization, and morphology.
Main Results:
- NMOFs exhibit exceptional porosity and high Brunauer-Emmett-Teller (BET) surface area.
- NMOFs demonstrate superior flexibility, biodegradability potential, and ease of functionalization compared to other nanocarriers.
- NMOFs can be synthesized in diverse morphologies, facilitating the encapsulation of various therapeutic agents like anticancer drugs and genes.
Conclusions:
- NMOFs represent a highly promising class of nanomaterials for advanced drug and gene delivery systems.
- The tailorable nature and unique properties of NMOFs position them as potent candidates for developing novel anticancer therapies.
- Further research into NMOF synthesis and functionalization will unlock their full potential in nanomedicine.
