Mesoporous Silica-Coated Upconverting Nanorods for Singlet Oxygen Generation: Synthesis and Performance

Photodynamic therapy (PDT) has been reported as a possible pathway for the treatment of tumors. The exploration for promising PDT systems thus attracts continuous research efforts. This work focused on an ordered core-shell structure encapsulated by mesoporous SiO₂ with the upconverting emission property following a surfactant-assisted sol-gel technique. The mesoporous silica shell possessed a high surface area-to-volume ratio and uniform distribution in pore size, favoring photosensitizer (rose bengal) loading. Simultaneously, upconverting nanocrystals were synthesized and used as the core. After modification via hydrophobic silica, the hydrophobic upconverting nanocrystals became hydrophilic ones. Under near-infrared (NIR) light irradiation, the nanomaterials exhibited strong green upconverting luminescence so that rose bengal could be excited to produce singlet oxygen. The photodynamic therapy (PDT) feature was evaluated using a ¹O₂ fluorescent indicator. It was found that this core-shell structure generates ¹O₂ efficiently. The novelty of this core-shell structure was the combination of upconverting nanocrystals with a mesoporous SiO₂ shell so that photosensitizer rose bengal could be effectively adsorbed in the SiO₂ shell and then excited by the upconverting core.