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Related Experiment Video

Updated: Oct 30, 2025

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

Microfluidic Obstacle Arrays Induce Large Reversible Shape Change in Red Blood Cells.

David W Inglis¹, Robert E Nordon², Jason P Beech³

¹School of Engineering, Macquarie University, Sydney, NSW 2109, Australia.

|July 2, 2021

Summary

This summary is machine-generated.

Red blood cells (RBCs) reversibly deform into unique shapes under shear stress, with deformation and recovery rates quantified. These findings offer insights into RBC disorders and microfluidic behavior.

Keywords:

DLD deterministic lateral displacement erythrocyte microfluidic morphology shear

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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

Biophysics
Hematology
Microfluidics

Background:

Red blood cell (RBC) mechanics under shear stress are crucial for understanding blood flow and diseases.
Previous studies have explored RBC deformation, but dynamic responses at high strain rates require further investigation.

Purpose of the Study:

To investigate the dynamic deformation and recovery rates of RBCs under periodic shear stress.
To characterize novel RBC shapes observed during high-speed deformation and relaxation.
To correlate RBC mechanical behavior with varying flow rates and shear stresses.

Main Methods:

High-speed time-lapse microscopy was employed to observe RBCs subjected to periodic shear stress.
Kaplan-Meier survival analysis was utilized to quantify deformation and recovery rates.
Controlled shear stress (2.2–25 Pa) and strain rates (2200–25,000 s⁻¹) were applied.

Main Results:

RBCs exhibited reversible deformation into previously unobserved shapes at shear stresses between 2.2 and 25 Pa.
Time to deformation decreased from 320 to 23 ms with increasing flow rates.
Shape recovery, indicating deformation extent, saturated at 2.4 s at 11.2 Pa shear stress.

Conclusions:

RBCs display complex, reversible shape changes under dynamic shear stress.
Quantified deformation and recovery rates provide critical data for RBC mechanics.
Findings are relevant for understanding RBC disorders and blood cell behavior in microfluidic devices.