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Updated: Oct 30, 2025

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
Published on: October 25, 2017
DNA-Directed Assembly of Carbon Nanotube-Protein Hybrids
Mark Freeley1, Rebecca E A Gwyther2, D Dafydd Jones2
1Department of Chemistry, Queen Mary University of London, London E1 4NS, UK.
Abstract:
Here, we report the controlled assembly of SWCNT-GFP hybrids employing DNA as a linker. Two distinct, enriched SWCNTs chiralities, (6,5), (7,6), and an unsorted SWCNT solution, were selectively functionalized with DNA and hybridized to a complementary GFPDNA conjugate. Atomic force microscopy images confirmed that GFP attachment occurred predominantly at the terminal ends of the nanotubes, as designed. The electronic coupling of the proteins to the nanotubes was confirmed via in-solution fluorescence spectroscopy, that revealed an increase in the emission intensity of GFP when linked to the CNTs.
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