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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Photosensitizing Antivirals.

Kseniya A Mariewskaya^1,2, Anton P Tyurin^1,3, Alexey A Chistov¹

¹Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Molecules (Basel, Switzerland)

|July 2, 2021

Summary

Photosensitizers that bind to lipid bilayers can generate singlet oxygen, a reactive molecule effective against enveloped viruses. This review highlights new compounds for broad-spectrum antiviral development.

Keywords:

BODIPY dyes broad-spectrum antivirals hypericin lipid bilayer perylene derivatives photosensitization singlet oxygen

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Area of Science:

Photochemistry
Virology
Biochemistry

Background:

Antiviral action of photosensitizers is complex and often empirically determined.
Mechanisms are difficult to elucidate, with many studies reporting phenomenological correlations.

Purpose of the Study:

To review lipid bilayer-affine photosensitizers with antiviral potential.
To summarize recent advancements in this field over the past three years.

Main Methods:

Literature review focusing on photosensitizers, singlet oxygen generation, and antiviral activity.
Analysis of photophysical properties and lipid bilayer affinity.

Main Results:

Singlet oxygen (¹O₂) generated by photosensitizers can damage viral envelopes.
Lipid bilayer-affine photosensitizers show promise as broad-spectrum antivirals against enveloped viruses.

Conclusions:

Targeted development of photosensitizers that bind to lipid membranes can lead to new antiviral strategies.
Further research into these compounds may accelerate the discovery of effective treatments for enveloped viral infections.