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Brain Invasion in Meningioma-A Prognostic Potential Worth Exploring
Felix Behling1,2, Johann-Martin Hempel2,3, Jens Schittenhelm2,4
1Department of Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.
Cancers
|July 2, 2021
Summary
Assessing central nervous system (CNS) invasion in meningioma is crucial for predicting recurrence risk. This review examines the evidence and challenges surrounding CNS invasion as a prognostic factor for meningioma patients.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Meningiomas, typically slow-growing tumors from arachnoid cap cells, are often curable by surgery or radiation.
- Recurrent and aggressive meningiomas pose treatment challenges due to limited alternatives.
- Accurate prognostication is vital for managing meningioma recurrence risk.
Purpose of the Study:
- To review the prognostic significance of central nervous system (CNS) invasion in meningioma.
- To discuss the challenges in histopathological assessment and intraoperative sampling of CNS invasion.
- To evaluate the future role of CNS invasion as a prognostic factor in meningioma.
Main Methods:
- Comprehensive review of existing literature on meningioma CNS invasion.
- Analysis of retrospective meningioma cohort data.
- Discussion of histopathological and imaging characteristics related to CNS invasion.
Main Results:
- Central nervous system (CNS) invasion has been linked to a higher risk of meningioma recurrence.
- Evidence supporting the prognostic impact of CNS invasion has been debated, leading to its proposed exclusion from WHO classifications.
- Recent studies confirm the prognostic value of CNS invasion, even when considering other established factors.
Conclusions:
- The prognostic impact of CNS invasion in meningioma requires further clarification.
- Standardization of histopathological assessment and intraoperative sampling is needed.
- CNS invasion remains a potential key factor for predicting meningioma recurrence and guiding treatment strategies.
