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Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments

Alicia González1, Carolina Alonso-González1, Alicia González-González1

  • 1Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Instituto de Investigación Valdecilla (IDIVAL), 39011 Santander, Spain.

Cancers
|July 2, 2021
PubMed

Insights

Melatonin, a hormone, inhibits tumor angiogenesis and enhances chemotherapy sensitivity. It counteracts chemotherapy-induced pro-angiogenic factors, acting as a potential radiosensitizer.

Area of Science:

  • Oncology
  • Endocrinology
  • Cancer Biology

Background:

  • Melatonin is a hormone with studied antitumor properties.
  • Inhibition of angiogenesis is a key antitumor mechanism of melatonin.
  • Melatonin's interaction with chemotherapy and radiotherapy is under investigation.

Purpose of the Study:

  • To review the interaction between melatonin and angiogenesis.
  • To outline mechanisms by which melatonin sensitizes cancer cells to treatment.
  • To explore melatonin's role in overcoming chemotherapy resistance.

Main Methods:

  • Literature review on melatonin's antiangiogenic and radiosensitizing effects.
  • Analysis of melatonin's impact on factors regulating angiogenesis.
  • Examination of synergistic effects of melatonin with chemotherapy and radiotherapy.

Main Results:

  • Melatonin exhibits antiangiogenic effects across various tumor types.
  • Combination therapy with melatonin and chemotherapy shows synergistic antiangiogenic effects.
  • Melatonin counteracts chemotherapy-induced pro-angiogenic factors and enhances tumor cell sensitivity to chemotherapy and radiotherapy.

Conclusions:

  • Melatonin's antiangiogenic properties contribute to its anticancer effects.
  • Melatonin can overcome cancer resistance to chemotherapy.
  • Melatonin acts as a radiosensitizer, enhancing the efficacy of cancer treatments.
Keywords:
angiogenesisantiangiogenic actionsbreast cancerchemotherapymelatoninradiotherapy

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