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Bleeding Disorders in Primary Fibrinolysis

Massimo Franchini1, Marco Zaffanello2, Pier Mannuccio Mannucci3

  • 1Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, 46100 Mantova, Italy.

International Journal of Molecular Sciences
|July 2, 2021
PubMed

Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype.

Keywords:
acquiredbleedinghemorrhageinheritedprimary hyperfibrinolysis

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