Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study on the metal composition characteristics of high-end bags in Korean domestic distribution using portable XRF.

Analytical methods : advancing methods and applications·2026
Same author

Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion MRI for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis.

Cerebrovascular diseases extra·2026
Same author

Comprehensive Prestroke Risk Factor Control and Functional Outcomes After Acute Ischemic Stroke.

Journal of the American Heart Association·2026
Same author

Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion.

Nature communications·2026
Same author

Promoter hypomethylation of <i>CDH7</i>: a novel epigenetic marker associated with cerebral small vessel disease.

Frontiers in genetics·2026
Same author

Inter-Crystal Spacing of Implantable Polymeric Surfaces as a Key Suppressor of Microbial Adhesion.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Oct 30, 2025

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

9.0K

Brain Connectivity Affecting Gait Function After Unilateral Supratentorial Stroke.

Hyun-Ah Lee1, Dae-Hyun Kim2

  • 1Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center, Seoul 05368, Korea.

Brain Sciences
|July 2, 2021
PubMed
Summary

Structural connectivity in the brain influences gait recovery after stroke. Diffusion tensor imaging can predict patient outcomes and guide rehabilitation strategies for improved walking ability.

Keywords:
connectivityfunctional recoverygaitneurorehabilitationstroke

More Related Videos

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.1K
Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

8.9K

Related Experiment Videos

Last Updated: Oct 30, 2025

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

9.0K
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

1.1K
Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

8.9K

Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Gait dysfunction is a significant long-term disability following stroke.
  • The precise mechanisms driving gait function recovery remain largely unknown.
  • Understanding these mechanisms is crucial for developing effective rehabilitation strategies.

Purpose of the Study:

  • To investigate the association between brain structural connectivity and gait function in stroke survivors.
  • To identify specific white matter pathways critical for motor recovery after unilateral supratentorial stroke.
  • To explore the utility of diffusion tensor imaging (DTI) in predicting gait recovery.

Main Methods:

  • Retrospective analysis of 127 patients with unilateral supratentorial stroke.
  • Utilized T1-weighted and diffusion tensor imaging (DTI) to assess brain structure.
  • Employed voxel-wise linear regression with functional ambulation categorization as the independent variable, controlling for age and time since stroke.

Main Results:

  • Positive associations were found between gait function and fractional anisotropy (FA) in the lesioned cortico-ponto-cerebellar system, non-lesioned corticospinal tract's corona radiata, bilateral brainstem medial lemniscus, and corpus callosum.
  • Increased mode of anisotropy (MD) in the lesioned posterior corpus callosum also correlated positively with gait function.
  • These findings highlight the role of structural integrity in motor coordination and feedback pathways.

Conclusions:

  • Structural connectivity, particularly within motor coordination and feedback networks, significantly impacts post-stroke gait function.
  • Diffusion tensor imaging (DTI) offers a valuable tool for assessing structural connectivity.
  • DTI can aid in predicting gait recovery trajectories and tailoring rehabilitation interventions for stroke patients.