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Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up

Ismail M Osmanov1,2,3, Ekaterina Spiridonova4,3, Polina Bobkova4,3

  • 1Z.A. Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.

The European Respiratory Journal
|July 2, 2021
PubMed

Insights

A quarter of children experienced persistent symptoms months after COVID-19 hospitalization. Older age and allergic diseases were linked to increased risk of these long-term symptoms in children.

Area of Science:

  • Pediatric infectious diseases
  • Long-term health outcomes
  • Epidemiology of emerging infections

Background:

  • Long-term effects of COVID-19 in children are not well understood.
  • Previous hospitalizations for COVID-19 in pediatric populations require further investigation.
  • Assessing sequelae in children post-COVID-19 infection is crucial for public health.

Purpose of the Study:

  • To evaluate the long-term health outcomes in children after hospital admission for COVID-19.
  • To identify risk factors associated with persistent symptoms in pediatric COVID-19 survivors.
  • To characterize the nature and prevalence of long-term sequelae in children post-COVID-19.

Main Methods:

  • Prospective cohort study including children (≤18 years) hospitalized with confirmed COVID-19.
  • Follow-up assessments conducted via telephone interviews using the ISARIC COVID-19 Health and Wellbeing Follow-up Survey for Children.
  • Persistent symptoms defined as those lasting >5 months and categorized by affected systems.

Main Results:

  • 61% of eligible children (518/853) participated in the follow-up.
  • 24.3% of participants reported persistent symptoms, most commonly fatigue, sleep disturbances, and sensory problems.
  • Older age (6-18 years) and a history of allergic diseases were significant risk factors for persistent symptoms.

Conclusions:

  • Persistent symptoms affect a significant proportion of children months after acute COVID-19 hospitalization.
  • Multisystem involvement was observed in nearly 10% of children with persistent symptoms.
  • Older children and those with allergic conditions face a higher risk of prolonged symptoms post-COVID-19.
Abstract

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