Facial Masking and SAMPPs: Potential "Variolation" in COVID-19

Variolation is an important phenomenon in the field of immunology and has a rich historical background that has changed the perception of immunity reinforcement in human beings.¹ This methodology was first used to immunize humans against smallpox infection by inoculating the infective material taken from infected patients.² The intention was to induce a mild form of infection that would germane antibody response for tackling the future smallpox infection. To be more precise the procedure involves the application of powered smallpox scabs or fluid obtained from the pustules of the infected patients. This application is on the superficial scratches made on the skin surface of normal healthy individuals.³ Thus, the variolation is the process in which the virus is inoculated in the patient to produce an antibody response. This process produces signs and symptoms similar to the intended viral infection but usually of the milder form, possibly due to mild quantum exposure of virus particles. In the case of smallpox, this methodology was first used in China, India, and the Middle East before it was introduced into England and North America in the 1720s.⁴ Due to advancements done in the field of vaccination, this crude method is no longer used today. However, this process was a milestone in science that has led to the development of many vaccines available nowadays.