Trauma Bay Time Clocks: Influence on Emergency Department Length of Stay

Jessica Hardway1, Damayanti Samanta, Kelly V Rennie

  • 1Department of Trauma Services, Charleston Area Medical Center, Charleston, West Virginia (Dr Hardway and Ms Evans); Center for Health Services and Outcomes Research, Charleston Area Medical Center Institute for Academic Medicine, Charleston, West Virginia (Ms Samanta); and West Virginia University School of Medicine-Charleston Division, Department of Surgery, Charleston Area Medical Center, Charleston, West Virginia (Drs Rennie and Lasky).

Abstract

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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