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High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
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Limb ischemia in patients with COVID-19

Julio Cesar Peclat de Oliveira1, Walter Jr Boim Araujo2, Sergio Quilici Belczak3

  • 1Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brasil.

Jornal Vascular Brasileiro
|July 2, 2021
PubMed

Insights

This review details life-threatening blood clots in COVID-19, including vascular damage and thrombosis. It covers coagulation management and anticoagulation strategies for patients with SARS-CoV-2 infection.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Hematology

Background:

  • SARS-CoV-2 infection, or COVID-19, is associated with a significant risk of thromboembolic events.
  • Understanding the pathophysiology of these events is crucial for effective patient management.

Purpose of the Study:

  • To provide a comprehensive review of life-threatening thromboembolic complications in COVID-19.
  • To discuss the vascular and arterial damage, coagulation laboratory management, and anticoagulation strategies.
  • To highlight the relationship between COVID-19 and deep venous thrombosis (DVT) and arterial thrombosis.

Main Methods:

  • Narrative review of existing literature.
  • Inclusion of clinical examples from patient experiences with COVID-19.

Main Results:

  • COVID-19 causes physical changes leading to vascular and arterial damage, particularly in the limbs.
  • The review emphasizes the link between SARS-CoV-2 infection and both deep venous thrombosis and arterial thrombosis.
  • Effective laboratory management of coagulation and appropriate anticoagulation are critical.

Conclusions:

  • Thromboembolic events represent a major life-threatening complication of COVID-19.
  • Management strategies should address vascular damage, coagulation abnormalities, and anticoagulation.
  • Further research and clinical vigilance are necessary to mitigate these risks.

Keywords:
COVID-19SARS-CoV-2anticoagulantsembolisms and thrombosisendovascular techniquesvascular diseases

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