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Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease

Liang Wang1, Yan Hu1, Baohui Song1

  • 1Research and Teaching Department of Comparative Medicine, Dalian Medical University, Dalian, 116044, China.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|July 2, 2021
PubMed

Insights

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway regulates immune responses in inflammatory bowel disease (IBD). Natural compounds show potential as novel JAK inhibitors for IBD treatment.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pharmacology

Background:

  • The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is crucial for cytokine signaling and immune regulation.
  • Dysregulation of the JAK/STAT pathway is implicated in initiating and perpetuating inflammatory responses, including those in inflammatory bowel disease (IBD).

Purpose of the Study:

  • To review the role of the JAK/STAT pathway in regulating immune cells within the context of IBD.
  • To discuss recent findings on JAK/STAT pathway involvement in intestinal immunity.
  • To summarize the therapeutic landscape of JAK inhibitors for IBD and explore natural remedies as potential JAK inhibitors.

Main Methods:

  • Literature review focusing on the JAK/STAT pathway in IBD.
  • Analysis of current JAK inhibitor therapies for IBD.
  • Identification and discussion of phytochemicals with potential JAK inhibitory activity.

Main Results:

  • The JAK/STAT pathway plays a significant role in both innate and adaptive immune responses relevant to IBD.
  • JAK inhibitors are an emerging therapeutic option for IBD treatment.
  • Several natural compounds (phytochemicals) exhibit potential as JAK inhibitors.

Conclusions:

  • The JAK/STAT pathway is a key regulator of intestinal immunity in IBD.
  • Targeting the JAK/STAT pathway with inhibitors, including those derived from natural sources, offers promising therapeutic strategies for IBD.
Keywords:
CytokineInflammatory bowel diseaseIntestinal inflammationJAK inhibitorJAK/STATTraditional Chinese medicine

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