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Infant T-cell acute lymphoblastic leukaemia with t(6;7) (TCRB-MYB) translocation
Pemantah Sandheeah Ramdeny1, Khushnuma Mullanfroze1, Paola de Lorenzo2,3
1Department of Haematology, Great Ormond Street Hospital, London, UK.
Insights
Infant T-cell Acute Lymphoblastic Leukaemia (T-ALL) is rare. Three cases of a specific T-ALL subtype, t(6;7) (TCR/MYB), presented with distinct central nervous system disease and refractory or relapsed outcomes.
Area of Science:
- Pediatric Oncology
- Hematology
- Molecular Biology
Background:
- T-cell Acute Lymphoblastic Leukaemia (T-ALL) is a rare malignancy in infants.
- The Interfant-06 trial identified a low incidence of T-ALL among infant ALL patients.
- Specific genetic alterations in infant T-ALL can influence clinical presentation and prognosis.
Abstract:
T-ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant-06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T-cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.
