Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.1K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advantages, limitations, and innovative considerations for established and emerging models of human placental syncytiotrophoblast.

Human reproduction update·2026
Same author

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models.

Cell proliferation·2025
Same author

Si<i>x</i>-Axis, Physiological Activity Profiles Create a More Challenging Cellular Environment in the Intervertebral Disc Compared to Single-Axis Loading.

ACS biomaterials science & engineering·2025
Same author

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models.

Molecular psychiatry·2024
Same author

Driving Osteocytogenesis from Mesenchymal Stem Cells in Osteon-like Biomimetic Nanofibrous Scaffolds.

ACS applied materials & interfaces·2024
Same author

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2.

Science advances·2024

Related Experiment Video

Updated: Oct 30, 2025

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

14.7K

High-Throughput Routes to Biomaterials Discovery.

Farhad Soheilmoghaddam1,2, Madeleine Rumble1,2, Justin Cooper-White1,2

  • 1Tissue Engineering and Microfluidics Laboratory (TEaM), Australian Institute for Bioengineering and Nanotechnology (AIBN), University Of Queensland, St. Lucia, Queensland, Australia 4072.

Chemical Reviews
|July 2, 2021
PubMed
Summary

Advancing regenerative medicine requires novel biomaterials. Combinatorial and high-throughput (HT) technologies accelerate the development and screening of these materials for tissue engineering and gene therapy applications.

More Related Videos

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

5.2K
Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
07:10

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes

Published on: September 29, 2023

4.0K

Related Experiment Videos

Last Updated: Oct 30, 2025

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

14.7K
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

5.2K
Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
07:10

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes

Published on: September 29, 2023

4.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Current treatments struggle to fully restore tissue function, especially with an aging population.
  • Gene therapy, tissue engineering, and regenerative medicine offer potential solutions for tissue repair and replacement.
  • Effective regenerative strategies depend on biomaterials that mimic the extracellular matrix to guide cell behavior.

Purpose of the Study:

  • To review advances in combinatorial and high-throughput (HT) technologies for biomaterial development.
  • To highlight the application of these technologies in gene therapy, tissue engineering, and regenerative medicine.
  • To discuss current limitations and future opportunities for HT biomaterial research.

Main Methods:

  • Review of recent literature on combinatorial and high-throughput (HT) approaches.
  • Focus on accelerated synthesis and characterization of polymeric biomaterials.
  • Integration of rapid screening techniques for cell and tissue interactions.

Main Results:

  • Combinatorial and HT technologies enable rapid synthesis and characterization of biomaterials.
  • These methods facilitate efficient screening of material properties and biological interactions.
  • Applications span gene therapy, tissue engineering, and regenerative medicine.

Conclusions:

  • Accelerated development of directive biomaterials is crucial for regenerative medicine.
  • High-throughput (HT) technologies are essential for optimizing biomaterial design and function.
  • Further integration of these methods promises significant advancements in treating tissue damage and dysfunction.