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Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Wenyi Lin1, Yu Wu2, Xuan Lu1

  • 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Aging
|July 2, 2021
PubMed

Insights

Mean platelet volume (MPV) is significantly higher in pulmonary embolism (PE) patients. Increased MPV also correlates with a higher risk of mortality in PE patients, suggesting its potential as a prognostic marker.

Area of Science:

  • Hematology
  • Cardiology
  • Pulmonary Medicine

Background:

  • Platelet activation is crucial in pulmonary embolism (PE) pathogenesis.
  • Mean platelet volume (MPV) is a potential indicator of platelet activity.
  • Existing research on the MPV-PE relationship yields inconsistent findings.

Purpose of the Study:

  • To systematically review and meta-analyze the association between MPV and PE.
  • To evaluate MPV as a potential biomarker for PE occurrence and mortality.

Main Methods:

  • Systematic literature search of databases from inception to April 21, 2021.
  • Inclusion of 18 studies after screening 2505 publications.
  • Data extraction and meta-analysis by two independent reviewers.

Main Results:

  • MPV was significantly elevated in PE patients compared to controls (mean difference 0.83 fL).
  • A significant difference in MPV was observed between PE non-survivors and survivors (mean difference 1.23 fL).

Conclusions:

  • Elevated MPV is associated with an increased risk of pulmonary embolism.
  • MPV may serve as a valuable prognostic tool for predicting PE occurrence and mortality risk.
Keywords:
early deathmean platelet volumemeta-analysispulmonary embolismrisk stratification

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