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Streptococcus pneumoniae serotype 3 genotypes in invasive isolates from Colombia

Zonia Katerin Alarcón1, Carolina Duarte2, Olga Sanabria3

  • 1Grupo de Microbiología, Instituto Nacional de Salud, Bogotá, D.C., Colombia. zoniakrod@gmail.com.

Biomedica : Revista Del Instituto Nacional De Salud
|July 2, 2021
PubMed
Abstract

Insights

Streptococcus pneumoniae serotype 3 infections increased in Colombia from 1994-2015. Most isolates belonged to the CC180 clone, with some showing antimicrobial resistance, indicating stable circulation.

Area of Science:

  • Microbiology
  • Epidemiology
  • Genetics

Background:

  • Streptococcus pneumoniae serotype 3 is a significant pathogen causing pneumonia, bacteremia, and meningitis.
  • Understanding the genetic diversity and evolution of S. pneumoniae serotypes is crucial for public health interventions.

Purpose of the Study:

  • To determine the circulating genotypes of Streptococcus pneumoniae serotype 3 isolates from invasive diseases in Colombia between 1994 and 2015.
  • To analyze the genetic relatedness and clonal evolution of S. pneumoniae serotype 3 in the Colombian population.

Main Methods:

  • Genotyping of 117 S. pneumoniae serotype 3 isolates using pulsed-field gel electrophoresis (PFGE).
  • Multilocus sequence typing (MLST) was performed on representative isolates.
  • Analysis of isolate data collected through a national laboratory surveillance program.

Main Results:

  • The frequency of S. pneumoniae serotype 3 increased significantly from 2.7% (1994-1998) to 9.1% (2011-2015).
  • Over 91% of isolates exhibited high genetic similarity (>77%), predominantly related to the Netherlands3-31 (PMEN31) clone CC180.
  • Antimicrobial resistance was identified in two subtypes of the CC180 clone.

Conclusions:

  • The pneumococcal population of capsular type 3 in Colombia demonstrates continuous and homogeneous circulation.
  • The clonal group ST-180 is the dominant genotype for S. pneumoniae serotype 3 in Colombia.
  • The findings highlight the importance of ongoing surveillance for S. pneumoniae serotype 3 and its evolving resistance patterns.
Keywords:
Streptococcus pneumoniaeelectrophoresisgelpulsed-fieldColombia

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