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A study of anticoagulant therapy in patients with coronary artery disease

Arina D Puspitasari1,2, Daniel Dwi Christiananta Salean3, Didik Hasmono1

  • 1Clinical Pharmacy Department, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

Journal of Basic and Clinical Physiology and Pharmacology
|July 2, 2021
PubMed

Insights

This study analyzed anticoagulant use in coronary artery disease (CAD) patients. While direct side effects were absent, interactions with other drugs increased bleeding risk.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Anticoagulant therapy is crucial for managing coronary artery disease (CAD).
  • Monitoring anticoagulant therapy is essential due to the significant risk of bleeding.
  • Evaluating adverse drug reactions and interactions is vital for patient safety in CAD management.

Purpose of the Study:

  • To analyze the anticoagulants prescribed for coronary artery disease (CAD) patients.
  • To identify potential adverse drug reactions associated with anticoagulant therapy in CAD.
  • To investigate adverse drug interactions involving anticoagulants in CAD patients.

Main Methods:

  • Observational study with retrospective data collection.
  • Inclusion criteria: CAD diagnosis with anticoagulant therapy, with or without complications/comorbidities.
  • Data from 40 patient medical records were descriptively analyzed.

Main Results:

  • Fondaparinux (45%), enoxaparin (37.5%), and warfarin (17.5%) were the primary anticoagulants used.
  • The majority of patients were male (80%) and aged 61-70 years (37.5%).
  • No direct side effects from the anticoagulants were reported.

Conclusions:

  • Fondaparinux, enoxaparin, and warfarin are commonly used anticoagulants in CAD patients.
  • While anticoagulants themselves showed no adverse effects, interactions with aspirin, clopidogrel, and allopurinol elevated bleeding risk.
  • Close monitoring for drug interactions is recommended for patients with CAD on anticoagulant therapy.
Abstract

Keywords:
anticoagulantscoronary artery diseasedrug-related problemsenoxaparinfondaparinuxwarfarin

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