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Updated: Oct 30, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Ethics and regulatory considerations for the clinical translation of somatic cell human epigenetic editing
Nikolajs Zeps1, Tamra Lysaght2, Ruth Chadwick3
1Eastern Health Clinical School, Monash University, Melbourne, VIC, Australia.
Abstract:
Altering the human epigenome with gene-editing technology in attempt to treat a variety of diseases and conditions seems scientifically feasible. We explore some of the ethical and regulatory issues related to the clinical translation of human epigenetic editing arguing that such approaches should be considered akin to somatic therapies.
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