Related Experiment Video

Updated: Oct 30, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.9K

NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a

Vaishali Aggarwal1, Hardeep Singh Tuli2, Mehmet Varol3

  • 1Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA.

Critical Reviews in Oncology/Hematology
|July 2, 2021
PubMed

Insights

Notch signaling is crucial for cell functions but can drive or suppress tumors. This review explores targeting Notch signaling for cancer treatment, including inhibitors in clinical trials.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Notch signaling is a conserved pathway vital for cell differentiation, development, and homeostasis.
  • Deregulation of Notch signaling is linked to tumor progression, making it a cancer therapeutic target.
  • The Notch pathway exhibits dual roles, acting as both an oncogene and a tumor suppressor.

Purpose of the Study:

  • To review the dual role of Notch signaling in cancer progression.
  • To discuss targeting Notch signaling for cancer treatment and management.
  • To present current information on Notch inhibitors in clinical trials and their combination therapies.

Main Methods:

  • Literature review of Notch signaling in cancer.
  • Analysis of Notch pathway's oncogenic and tumor-suppressive functions.
  • Compilation of data on Notch inhibitors in clinical trials.

Main Results:

  • Notch signaling drives key hallmarks of tumor progression.
  • Notch pathway's complex role necessitates careful therapeutic targeting.
  • Several Notch inhibitors are under clinical investigation for various cancers.

Conclusions:

  • The Notch pathway's dynamic role in cancer requires nuanced therapeutic strategies.
  • Targeting Notch signaling holds promise for cancer treatment, especially in combination therapies.
  • Ongoing clinical trials for Notch inhibitors suggest potential advancements in cancer management.
Keywords:
CancerHallmarksNOTCHTherapeutic targets

More Related Videos

Stimulation of Notch Signaling in Mouse Osteoclast Precursors08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.1K
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.0K

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K