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A meta-analysis on sleep quality in inflammatory bowel disease
Andrea Ballesio1, Andrea Zagaria1, Flavia Baccini2
1Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy.
Sleep Medicine Reviews
|July 2, 2021
Summary
Patients with inflammatory bowel disease (IBD) experience poorer subjective sleep quality compared to controls. Active IBD is linked to significantly worse sleep, highlighting sleep
Area of Science:
- Gastroenterology and Sleep Medicine
- Investigating the intricate relationship between chronic gastrointestinal inflammation and sleep disturbances.
Background:
- Growing evidence suggests a link between inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, and diminished sleep quality.
- However, a comprehensive systematic review and meta-analysis on this topic has been lacking.
Purpose of the Study:
- To systematically review and meta-analyze existing studies on sleep quality in patients with IBD.
- To compare sleep quality between IBD patients and healthy controls, across IBD subtypes, and between active and inactive disease states.
Main Methods:
- Conducted a systematic review and meta-analysis of studies comparing sleep quality.
- Searched major databases (PubMed, Medline, PsycINFO, Scopus, CINAHL) up to March 2021.
- Included 42 studies examining standardized sleep quality measures in IBD patients versus controls, Crohn's disease versus ulcerative colitis, and active versus inactive IBD.
Main Results:
- IBD patients reported significantly poorer subjective sleep quality than controls (moderate effect size).
- No significant differences in sleep quality were observed between Crohn's disease and ulcerative colitis subtypes.
- Individuals with active IBD exhibited poorer sleep quality compared to those in remission (large effect size). Objective sleep data showed mixed results.
- Subjective poor sleep quality is a significant comorbidity in IBD.
Conclusions:
- Subjective poor sleep quality is a relevant comorbidity in inflammatory bowel disease.
- Sleep quality may influence immune responses and patients' quality of life.
- Integrating sleep assessment and management into IBD treatment plans is recommended.
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