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Quantification of smooth pursuit dysfunction in multiple sclerosis
Torge Rempe1, Neda Dastgheyb1, Annalise Miner1
1Dept. of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Background:
Smooth pursuit dysfunction is common in MS, but rarely quantified and may be missed on exam.
Methods:
NeuroFitONE™ smooth pursuit performance measures were compared between MS (n = 20) and healthy control (n = 19) participants.
Results:
Compared to controls, MS patients had lower proportion of smooth pursuit (0.63 vs. 0.73; p = 0.047), increased directional (10.1 vs. 8°; p = 0.014) and speed noise (4.3 vs. 3.1°/sec; p = 0.021) and reduced initiation acceleration (96.83 vs. 115.33°/sec2; p = 0.061). Significant univariate correlations with clinical scores (EDSS, T25-FW) were observed.
Conclusion:
Smooth pursuit dysfunction in MS can be readily quantified and distinguishes MS eyes from healthy controls.
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