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Quantification of smooth pursuit dysfunction in multiple sclerosis.

Torge Rempe1, Neda Dastgheyb1, Annalise Miner1

  • 1Dept. of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Multiple Sclerosis and Related Disorders
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Smooth pursuit dysfunction is common in multiple sclerosis (MS). This study quantified eye movement abnormalities in MS patients, revealing significant differences compared to healthy individuals.

Keywords:
Efferent visual system dysfunctionEye trackerSaccadic breakdown of smooth pursuit

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Area of Science:

  • Ophthalmology
  • Neurology
  • Biomedical Engineering

Background:

  • Smooth pursuit eye movement dysfunction is a frequent but often undetected clinical sign in multiple sclerosis (MS).
  • Quantifying these subtle neurological deficits is crucial for accurate diagnosis and monitoring disease progression.

Purpose of the Study:

  • To investigate and quantify smooth pursuit eye movement performance in individuals with MS.
  • To compare smooth pursuit metrics between MS patients and healthy controls using a novel assessment tool.

Main Methods:

  • Utilized the NeuroFitONE™ system to measure smooth pursuit performance.
  • Compared eye movement data from 20 MS patients against 19 healthy control participants.

Main Results:

  • MS patients exhibited a lower proportion of smooth pursuit compared to controls (0.63 vs. 0.73, p=0.047).
  • Participants with MS showed increased directional (10.1° vs. 8°, p=0.014) and speed noise (4.3°/sec vs. 3.1°/sec, p=0.021).
  • Reduced initiation acceleration was observed in MS patients (96.83°/sec² vs. 115.33°/sec², p=0.061), with correlations to clinical scores (EDSS, T25-FW).

Conclusions:

  • Smooth pursuit eye movement abnormalities in MS are quantifiable using the NeuroFitONE™ system.
  • These quantified deficits effectively differentiate individuals with MS from healthy controls.
  • Objective measurement of smooth pursuit dysfunction offers a valuable tool for MS assessment.