Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

pH Homeostasis01:31

pH Homeostasis

17.3K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
17.3K
Homeostatic Imbalance01:10

Homeostatic Imbalance

30.2K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
30.2K
What is Homeostasis?01:16

What is Homeostasis?

49.4K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
49.4K
Introduction to Chemical Reactions01:23

Introduction to Chemical Reactions

11.0K
All chemical reactions begin with a reactant, the general term for one or more substances entering the reaction. Sodium and chloride ions, for example, are the reactants in the production of table salt. One or more substances produced by a chemical reaction are called the product. Chemical reactions follow the law of conservation of mass, which means that matter cannot be created nor destroyed in a chemical reaction. The components of the reactants—the number of atoms and the...
11.0K
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

21.5K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
21.5K
Stomach pH Regulation01:21

Stomach pH Regulation

6.4K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Choline-dependent methionine metabolism supports leukemia progression.

Communications biology·2026
Same author

Genomic characterization of multidrug-resistant Klebsiella pneumoniae clinical isolates from India.

Scientific reports·2026
Same author

Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay.

Gut microbes·2026
Same author

Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.

Cell metabolism·2026
Same author

Frontiers of redox biology.

Nature chemical biology·2026
Same author

BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes.

Molecular cell·2026
Same journal

Tomogram exploration through template matching and deep learning.

Current opinion in structural biology·2026
Same journal

A comparative review of cryo-electron ptychography: Biological applications and future perspectives.

Current opinion in structural biology·2026
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
See all related articles

Related Experiment Video

Updated: Oct 30, 2025

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

3.8K

Structural perspectives on H2S homeostasis.

Aaron P Landry1, Joseph Roman1, Ruma Banerjee1

  • 1Department of Biological Chemistry, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Current Opinion in Structural Biology
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Hydrogen sulfide (H₂S) homeostasis is regulated by key enzymes like cystathionine beta-synthase (CBS) and sulfide quinone oxidoreductase (SQOR). Understanding their structure and mechanisms is vital for health and disease research.

More Related Videos

A Simple Approach to Manipulate Dissolved Oxygen for Animal Behavior Observations
06:20

A Simple Approach to Manipulate Dissolved Oxygen for Animal Behavior Observations

Published on: June 28, 2016

9.5K
Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
10:24

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

Published on: June 7, 2018

8.8K

Related Experiment Videos

Last Updated: Oct 30, 2025

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

3.8K
A Simple Approach to Manipulate Dissolved Oxygen for Animal Behavior Observations
06:20

A Simple Approach to Manipulate Dissolved Oxygen for Animal Behavior Observations

Published on: June 28, 2016

9.5K
Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
10:24

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

Published on: June 7, 2018

8.8K

Area of Science:

  • Biochemistry
  • Enzymology
  • Metabolic Regulation

Background:

  • Hydrogen sulfide (H₂S) is a crucial signaling molecule involved in cellular homeostasis.
  • Enzymes like cystathionine beta-synthase (CBS) and sulfide quinone oxidoreductase (SQOR) are central to H₂S production and metabolism.
  • Dysregulation of H₂S homeostasis is implicated in various diseases.

Purpose of the Study:

  • To provide structural perspectives on the reaction mechanisms and regulation of CBS and SQOR.
  • To elucidate the role of these enzymes in maintaining H₂S homeostasis.
  • To explore the implications of their dysregulation in disease.

Main Methods:

  • Review of existing literature on enzyme structures and functions.
  • Analysis of reaction mechanisms and regulatory pathways.
  • Integration of structural data with metabolic pathways.

Main Results:

  • CBS commits homocysteine to cysteine, influencing H₂S production.
  • SQOR facilitates H₂S oxidation via mitochondrial pathways, impacting cellular respiration.
  • Inborn errors in CBS or SQOR lead to distinct metabolic disruptions.

Conclusions:

  • Structural insights into CBS and SQOR are key to understanding H₂S homeostasis.
  • Targeting these enzymes offers potential therapeutic strategies for H₂S-related diseases.
  • Further research into enzyme mechanisms can illuminate H₂S's role in health and disease.