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Large-scale flow analysis: From repetitive assays to expert analyzers
Elias A G Zagatto1, Fábio R P Rocha1
1Center for Nuclear Energy in Agriculture, University of Sao Paulo, P.O. Box 96, Piracicaba, 13400-970, Brazil.
Talanta
|July 3, 2021
Summary
Expert flow analyzers utilize computer-controlled systems for real-time assay optimization. This review details the evolution of flow analysis from repetitive to intelligent, adaptive methods for diverse sample types.
Area of Science:
- Analytical Chemistry
- Laboratory Automation
Background:
- Traditional flow analysis involves repetitive assays with uniform sample handling.
- Computer-controlled devices enable individualized sample processing through manifold dimensioning.
Purpose of the Study:
- To review the evolution of flow analysis from repetitive to real-time defined assays.
- To highlight trends in expert flow analyzers and their applications.
Main Methods:
- Exploitation of computer-controlled devices (pumps, valves, injectors).
- Implementation of manifold re-dimensioning via flow/manifold programming, often using multicommutation.
- Integration of real-time feedback mechanisms for system optimization.
Main Results:
- Shift from repetitive to adaptive flow analysis methods.
- Improved analytical figures of merit, laboratory management, and fault detection.
- Broad applicability across agronomical, clinical, environmental, industrial, pharmaceutical, and geological samples.
Conclusions:
- Expert flow analyzers represent a significant advancement in analytical chemistry.
- Real-time adaptive capabilities enhance efficiency, accuracy, and versatility in flow analysis.
